In this episode, Dr. C tries to explain the complexity of the human genome. Problem is, nobody understands it because it is too complex! He compares the genome to a computer operating system, but this quickly gets eclipsed by what he calls the four-dimensional genome.
Location: Mid-America Windmill Museum
Links and sources:
Bolzer A, et al., Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes, PLoS Biol 3(5):e157, 2005.
Duncan AW, et al., The ploidy conveyor of mature hepatocytes as a source of genetic variation, Nature 467:707-710, 2010.
Baillie JK, et al., Somatic retrotransposition alters the genetic landscape of the human brain, Nature 479:534-537, 2011.
Xue S, Barna M, Specialized ribosomes: a new frontier in gene regulation and organismal biology, Nature Reviews Molecular Cell Biology 13:355–369, 2012.